A visit to the city can start at the church/museum of San Francesco, where one will find a fusion of Montefalco history, culture and tradition. Built between 1335 and 1338 by the minor friars, it was the third Franciscan settlement in the Montefalco area and the first within the city walls. The church, officiated until 1863, in that year became the property of the Municipality and in 1895 became the seat of the Civic Museum. Since 1990, the museum has been articulated into three exhibition spaces: the former church, the picture gallery and the crypt. The former church, famous all over the world for its frescoes by Benozzo Gozzoli (1452), which depict episodes from the life of Saint Francis, also preserves a Nativity by Perugino and fifteenth-century frescoes by the Umbrian school. The picture gallery houses mobile works by Francesco Melanzio, a Montefalco painter, Antoniazzo Romano, the workshop of Niccolò Alunno and Melozzo da Forlì, Umbrian school paintings from between the fourteenth and eighteenth century and a collection of Minor Arts. In the crypt, one finds archaeological finds, sculptures and fragments from various periods. In 2009, the old cellars of the Conventual Friars of Montefalco were made accessible to the public. The museum complex also offers exhibition spaces dedicated to temporary contemporary art exhibitions. The road faced by the church-museum of San Francesco leads straight to the beautiful circular piazza where one finds the Palazzo del Comune (thirteenth-fourteenth century), the former church of San Filippo Neri (eighteenth century), now a theatre, the church of S. Maria (thirteenth century) and important examples of lordly residences of the sixteenth century.

In the oldest part of the medieval town, near the Porta di Camiano, one will note the precise regularity of the façade of the small church of Santa Lucia (late twelfth century) and the Sagrantino grape vines that, stubbornly, remain to tell of the ancient presence of cultivated vines surrounded by high garden walls.

The itinerary focused on Montefalco religious art can continue with a visit to the church of Sant'Agostino of the Augustinian community. Many artists worked here, including Ambrogio Lorenzetti and Bartolomeo Caporali.

The Renaissance also gave Montefalco a gracious religious building: the church of Sant'Illuminata (sixteenth century), embellished with frescoes by Francesco Melanzio and other Umbrian painters. In front stands the church of San Leonardo, annexed to a Clarisse convent. On the same road one finds the architectural heart of this part of the city of monasteries: the stately building dedicated to the Augustinian Santa Chiara da Montefalco (1268-1308). In the Sanctuary of Santa Chiara one finds relics of the Saint and the Chapel of Santa Croce, decorated in 1333 with important frescoes by the Umbrian school. The city walls of Montefalco are preserved almost intact. They were documented as early as 1216 and in 1225 seem to have already undergone an expansion necessitated by demographic growth that then continued until the end of the sixteenth century.

Of particular importance are the city gates: Porta Camiano, Porta Sant'Agostino, Porta San Bartolomeo (now called Porta Federico II),  Porta della Rocca and Porta di San Leonardo. Outside the walls, along roads that wind through nature and sites of Franciscan spirituality, one finds the monastery of San Fortunato, interesting in terms of art due to the presence of works by Benozzo Gozzoli and Tibero d'Assisi, who frescoed the chapel delle Rose located beneath the portico opposite the church. Here one also finds the sanctuary of the Madonna della Stella, with important nineteenth-century paintings, and the church of Santa Maria di Turrita, rich in devotional frescoes dating from the fourteenth to the sixteenth century.  In the environs, one should visit the fraction of Fabbri to see the ruins of a fourteenth-century castle which was part of the Albornoz defence system.